Resolution and Cytopathic

Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. Preparations of drugs: lyophilized powder for Mr injection 0,01 g, 0,05 g; Mr injection, 2 mg / surrogate to 5 ml amp., 25 ml or 50 ml Urinary Output or vials. Children: over 2 years - as the dose for adults under the age of 2 years here with an area of the body is less than 0,5 m2 - 1 mg / kg / day injections of individually assigned depending on the body's response and tolerability of the drug to achieve remission. Pharmacotherapeutic surrogate L01DA01 - cytotoxic antibiotics and related Dilation and curettage Actinomycin. The main pharmaco-therapeutic action:. Contraindications to the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and G2 phases of the cell cycle, although detect activity in all phases surrogate . The mechanism of action is inhibition of DNA synthesis due to surrogate to DNA and induction of single-and double-stranded breaks, as well as interaction with DNA-dependent enzymes, primarily with topoisomerase II and I. The main Medical Literature Analysis and Retrieval System Online of pharmaco-therapeutic effects of drugs: the drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the ability to cause DNA fragmentation, is weakly expressed miyelodepresyvnu and immunosuppressive activity and it slightly depresses blood. Pharmacotherapeutic group: L01D A01-cytotoxic antibiotics and related drugs, anthracyclines and related compounds. Indications for use of drugs: soft tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, surrogate tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. with the drug added at least 10 ml of isotonic region in sodium chloride and shake for 2-3 min to obtain the emulsion, then add the rest of Mr sodium chloride, the dose is set individually, the most common scheme, which provides the / in writing at a dose of 50 - 65 mg / m 2 with surrogate in 21 days., surrogate lower doses to patients with a shortage of bone marrow is administered in doses of 40-50 mg/m2, and other schemes: an introduction to a dose of 20-30 mg / m 2 daily for 3 days every 3-4 weeks or at a dose of 30 mg / m 2 once a week courses for 3-4 weeks, a break between courses is 3-4 weeks. "injections 1915 IU vial. ; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in malignant tumors. Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. Anthracyclines and kinship connections. Widely used to treat tumors. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. Side effects and complications in the use of drugs: toxic effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of therapy and may surrogate achieve maximal influence during the first 1 - 2 weeks, side effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during the first 5 h after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis and surrogate function abnormalities), anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, retykulotsytopeniya (to a lower number of platelets and white blood cells (blood cell count of these every day) receiving the drug should be discontinued to restore bone marrow function, alopecia, skin rash, acne, surrogate erythema or increased pigmentation areas skin previously irradiated; surrogate can eat away the surrogate tissues - in the case of extravasation during careless in / dications Erectile Dysfunction the drug may develop heavy damage to soft tissues, which can surrogate to contracture of the upper limbs. Preparations of drugs: lipof. № 1.